This study evaluated effects of coping for two major disease-related stressors, diseaserelated daily discomfort and disease-related anxiety for the future, on stress responses in 30 adolescent patients with nephrotic syndrome. Patients were requested to complete the scales for stress responses in adolescents and the coping scales for stressors. The coping scales for stressors consist of two independent strategies, approaching coping and avoidant coping. Patients who had high stressor scores against disease-related daily discomfort significantly showed high stress responses when they applied approaching coping strategy. However, the scores of stress responses were significantly reduced by the application of avoidant coping strategy. On the other hand, patients who had high stressor scores against disease-related anxiety for the future showed low stress responses when they applied approaching strategy. The scores of stress responses were not reduced by the application of avoidant coping strategy. These results suggest that the specific coping strategy for the individual stressor significantly reduce stress responses. Thus, the application of suitable coping strategy may play an important role in the management of the psychological stress in patients with nephrotic syndrome.