In this study, we investigated whether the working memory involved the post-lexical semantic integration process whereby semantic information was integrated into a higher level discourse representation. ERPs were recorded from twelve undergraduate and graduate students during the lexical decision task under low or high working memory load conditions. Perticipants decided whether target was a real word or not with keeping two or five digits in working memory. The N400 reflecting the ease of semantic integration were smaller for targets preceded by related primes than prededed by unrelated primes. This N400 modutation, however, was not affected by memory load. It is suggested that the different working memory subsystem for retaining digits is engaged in the semantic integration underlying the N400.