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Hiroshima Journal of Medical Sciences 33 巻 4 号
1984-12 発行
Effect of Low Dose X-Irradiation on Alloantigen Sensitized and Unsensitized Lymphocytes
アロ抗原感作および未感作リンパ球に対する低線量X線照射の効果
Dohi Kiyohiko
Yahata Hiroshi
Fukuda Yasuhiko
Asahara Toshimasa
Ono Eiji
Ezaki Haruo
Abstract
The effect of local graft irradiation on immune response in allograft in which acute rejection occurs was studied using an in vitro model. Unidirectional mixed lymphocyte culture (MLC) was used as the in vitro model of acute rejection. 150 and 300 rad x-irradiation suppressed mixed lymphocyte reaction (MLR) but did not cell-mediated-lympholysis (CML) of unsensitized lymphocytes. X-irradiated alloantigen sensitized cells (ASC) generated in 6-day MLC suppressed MLR and CML of unsensitized lymphocytes. Suppressive effects of x-irradiated ASC were of the same degree by x-irradiation doses of 150-500 rad. Suppressive effect of x-irradiation was maintained for only a short period after x-irradiation. Potential function of suppressor precursor cells among unsensitized lymphocytes was abolished by x-irradiation of 300 rad.
About This Article
著者キーワード
Rejection
Local graft irradiation
MLR
CML
Other Article
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