この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00038267
Hiroshima Journal of Medical Sciences 33 巻 4 号
1984-12 発行
Studies of Standard Liver Function and Hepatic Fibrosis in Rats with Obstructive Jaundice and Biliary Drainage
閉塞性黄疸及び減黄ラットにおける一般肝機能と肝線維化の検討
Takeuchi Hitoshi
Kodama Osamu
Ito Nobuaki
Tanaka Tsuneo
Harada Mitsuo
Seikoh Rokuro
Yamamoto Masami
Ezaki Haruo
Abstract
The authors prepared the obstructive jaundice model on which the external biliary drainage was operable, and tried to clarify the critical duration of obstruction from the aspects of the standard liver function and hepatic fibrosis, and the following results were obtained.
1) The T. B, Al-p, GOT and GPT levels in 1 to 4 weeks after the common bile duct obstruction was significantly high (p<0.01) as compared with the normal levels, but no definite differences were found between each period of obstruction. After the biliary drainage was performed for 5 days in each period of obstruction, the GOT level was significantly high (p<0.05) as compared with the normal level in 1, 3 and 4 weeks, but no significantly differences were noted in the T. B, Al-p and GPT levels in 1 to 4 weeks.
2) Classifying the severity of hepatic fibrosis into the scores from 0 to 3, the severity score of hepatic fibrosis indicated higher levels with the prolongation of the common bile duct obstruction, and significant differences were observed between 1 and 2 weeks (p<0.05), and between 3 and 4 weeks (p<0.01). The severity score of hepatic fibrosis after biliary drainage showed significantly lower levels (p<0.05) as compared with the common bile duct obstruction in 1 to 3 weeks. In 4 weeks, however, no significant difference was noted.
1) The T. B, Al-p, GOT and GPT levels in 1 to 4 weeks after the common bile duct obstruction was significantly high (p<0.01) as compared with the normal levels, but no definite differences were found between each period of obstruction. After the biliary drainage was performed for 5 days in each period of obstruction, the GOT level was significantly high (p<0.05) as compared with the normal level in 1, 3 and 4 weeks, but no significantly differences were noted in the T. B, Al-p and GPT levels in 1 to 4 weeks.
2) Classifying the severity of hepatic fibrosis into the scores from 0 to 3, the severity score of hepatic fibrosis indicated higher levels with the prolongation of the common bile duct obstruction, and significant differences were observed between 1 and 2 weeks (p<0.05), and between 3 and 4 weeks (p<0.01). The severity score of hepatic fibrosis after biliary drainage showed significantly lower levels (p<0.05) as compared with the common bile duct obstruction in 1 to 3 weeks. In 4 weeks, however, no significant difference was noted.
About This Article
著者キーワード
Hepatic fibrosis
Obstructive jaundice
Biliary drainage
Other Article
PP. 571 - 575
PP. 585 - 589
PP. 591 - 594
PP. 595 - 598
PP. 607 - 614
PP. 615 - 618
PP. 619 - 624
PP. 649 - 657
PP. 659 - 662
PP. 679 - 683
PP. 715 - 720
PP. 727 - 730
PP. 747 - 754
PP. 755 - 758
PP. 759 - 763
PP. 771 - 774
PP. 813 - 817