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Hiroshima Journal of Medical Sciences 33 巻 4 号
1984-12 発行

Facilitated Secretion of Pressor Amounts of Vasopressin in Spontaneously Hypertensive Rats

高血圧自然発症ラットにおける昇圧量パゾプレシン分泌の促進
Iriuchijima Juro
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HiroshimaJMedSci_33_571.pdf
Abstract
Vasopressin antagonist, which antagonizes pressor effect of vasopressin, was injected　to spontaneously hypertensive rats under various conditions to observe whether arterial　pressure was decreased to indicate secretion of pressor amounts of vasopressin. Vasopressin was secreted in pressor amounts in spontaneously hypertensive rats after acute spinal transection or sinoaortic denervation. This is in sharp contrast to normal rats in which ganglion blockade with hexamethonium bromide is necessary in addition to spinal transection or sinoaortic denervation for secretion of pressor amounts of vasopressin. This indicates that vasopressin secretion in pressor amounts is faciliated in spontaneously hypertensive rats.
About This Article
著者キーワード
Spontaneously hypertensive rat
SHR
Vasopressin
Baroreceptor
Volume receptor
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