A case of Cronkhite-Canada Syndrome (CCS), a 58-year old male, is reported. The case, who had multiple polypoid lesions in the stomach and colon, was hospitalized in a cachexic condition due to malabsorption with the chief complaint of watery diarrhea. Distal gastrectomy and total colectomy were performed due to marked watery diarrhea and the diagnosis of gastric cancer upon biopsy of the gastric polyp. After hospitalization, the case presented the typical ectodermal syndrome of hair loss, skin pigmentation and nail atrophy, but at present, ten months after his operation, his symptoms have improved and his general condition is stable and he lives a normal social life.