Studies of Standard Liver Function and Hepatic Fibrosis in Rats with Obstructive Jaundice and Biliary Drainage

閉塞性黄疸及び減黄ラットにおける一般肝機能と肝線維化の検討

Takeuchi Hitoshi

Kodama Osamu

Ito Nobuaki

Tanaka Tsuneo

Harada Mitsuo

Seikoh Rokuro

Yamamoto Masami

Ezaki Haruo

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

The authors prepared the obstructive jaundice model on which the external biliary drainage was operable, and tried to clarify the critical duration of obstruction from the aspects of the standard liver function and hepatic fibrosis, and the following results were obtained.

1) The T. B, Al-p, GOT and GPT levels in 1 to 4 weeks after the common bile duct obstruction was significantly high (p<0.01) as compared with the normal levels, but no definite differences were found between each period of obstruction. After the biliary drainage was performed for 5 days in each period of obstruction, the GOT level was significantly high (p<0.05) as compared with the normal level in 1, 3 and 4 weeks, but no significantly differences were noted in the T. B, Al-p and GPT levels in 1 to 4 weeks.

2) Classifying the severity of hepatic fibrosis into the scores from 0 to 3, the severity score of hepatic fibrosis indicated higher levels with the prolongation of the common bile duct obstruction, and significant differences were observed between 1 and 2 weeks (p<0.05), and between 3 and 4 weeks (p<0.01). The severity score of hepatic fibrosis after biliary drainage showed significantly lower levels (p<0.05) as compared with the common bile duct obstruction in 1 to 3 weeks. In 4 weeks, however, no significant difference was noted.

Hepatic fibrosis

Obstructive jaundice

Biliary drainage

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 6534925