Effect of Low Dose X-Irradiation on Alloantigen Sensitized and Unsensitized Lymphocytes
Hiroshima Journal of Medical Sciences 33 巻 4 号
759-763 頁
1984-12 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Effect of Low Dose X-Irradiation on Alloantigen Sensitized and Unsensitized Lymphocytes
|
| タイトル ( jpn ) |
アロ抗原感作および未感作リンパ球に対する低線量X線照射の効果
|
| 作成者 |
Dohi Kiyohiko
Yahata Hiroshi
Fukuda Yasuhiko
Asahara Toshimasa
Ono Eiji
Ezaki Haruo
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 33 |
| 号 | 4 |
| 開始ページ | 759 |
| 終了ページ | 763 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
The effect of local graft irradiation on immune response in allograft in which acute rejection occurs was studied using an in vitro model. Unidirectional mixed lymphocyte culture (MLC) was used as the in vitro model of acute rejection. 150 and 300 rad x-irradiation suppressed mixed lymphocyte reaction (MLR) but did not cell-mediated-lympholysis (CML) of unsensitized lymphocytes. X-irradiated alloantigen sensitized cells (ASC) generated in 6-day MLC suppressed MLR and CML of unsensitized lymphocytes. Suppressive effects of x-irradiated ASC were of the same degree by x-irradiation doses of 150-500 rad. Suppressive effect of x-irradiation was maintained for only a short period after x-irradiation. Potential function of suppressor precursor cells among unsensitized lymphocytes was abolished by x-irradiation of 300 rad.
|
| 著者キーワード |
Rejection
Local graft irradiation
MLR
CML
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| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
|
| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
|
| 発行日 | 1984-12 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6242053
|
