Effect of Low Dose X-Irradiation on Alloantigen Sensitized and Unsensitized Lymphocytes
Hiroshima Journal of Medical Sciences Volume 33 Issue 4
Page 759-763
published_at 1984-12
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| File | |
| Title ( eng ) |
Effect of Low Dose X-Irradiation on Alloantigen Sensitized and Unsensitized Lymphocytes
|
| Title ( jpn ) |
アロ抗原感作および未感作リンパ球に対する低線量X線照射の効果
|
| Creator |
Dohi Kiyohiko
Yahata Hiroshi
Fukuda Yasuhiko
Asahara Toshimasa
Ono Eiji
Ezaki Haruo
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 33 |
| Issue | 4 |
| Start Page | 759 |
| End Page | 763 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
The effect of local graft irradiation on immune response in allograft in which acute rejection occurs was studied using an in vitro model. Unidirectional mixed lymphocyte culture (MLC) was used as the in vitro model of acute rejection. 150 and 300 rad x-irradiation suppressed mixed lymphocyte reaction (MLR) but did not cell-mediated-lympholysis (CML) of unsensitized lymphocytes. X-irradiated alloantigen sensitized cells (ASC) generated in 6-day MLC suppressed MLR and CML of unsensitized lymphocytes. Suppressive effects of x-irradiated ASC were of the same degree by x-irradiation doses of 150-500 rad. Suppressive effect of x-irradiation was maintained for only a short period after x-irradiation. Potential function of suppressor precursor cells among unsensitized lymphocytes was abolished by x-irradiation of 300 rad.
|
| Keywords |
Rejection
Local graft irradiation
MLR
CML
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1984-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6242053
|
