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Hiroshima Journal of Medical Sciences Volume 33 Issue 4
published_at 1984-12
Influence of Hemoperfusion Using Polyetherurethane Sheet Embedded with Powdered Charcoal (UPC) on Middle Molecules of Hepatic Failure Dogs
粉状活性炭シート（UPC)を用いた血液灌流による胚不全犬中分子量物質の変動
Kawanishi Hideki
Nishiki Masayuki
Kanao Motoo
Nakagawa Kenichi
Sugiyama Masafumi
Tsuchiya Taro
Ezaki Haruo
Abstract
Plasma taken from hepatic failure dogs induced by hepatic ischemia was used to observe the variation in its chromatogram obtained by conducting a high performance gel-chromatography (TSK G2000SW used). The progress of hepatic failure caused a distinct increase in the middle molecular (MM) fractions (m. w. over 500), which showed a good correlation with the condition of progressing hepatic failure. The reduction of the above number of peaks was observed when the hemoperfusion was performed using the polyetherurethane sheet embedded with powdered charocal (UPC) that had been newly developed mainly for the purpose of absorbing protein-bound substances. The UPC developed by the authors can successfully remove middle molecular substances in hepatic failure.
About This Article
Keywords
Middle molecules
High performance gel-chromatography
Charcoal
UPC
Hemoperfusion
Liver support
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