Influence of Hemoperfusion Using Polyetherurethane Sheet Embedded with Powdered Charcoal (UPC) on Middle Molecules of Hepatic Failure Dogs

粉状活性炭シート（UPC)を用いた血液灌流による胚不全犬中分子量物質の変動

Kawanishi Hideki

Nishiki Masayuki

Kanao Motoo

Nakagawa Kenichi

Sugiyama Masafumi

Tsuchiya Taro

Ezaki Haruo

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

Plasma taken from hepatic failure dogs induced by hepatic ischemia was used to observe the variation in its chromatogram obtained by conducting a high performance gel-chromatography (TSK G2000SW used). The progress of hepatic failure caused a distinct increase in the middle molecular (MM) fractions (m. w. over 500), which showed a good correlation with the condition of progressing hepatic failure. The reduction of the above number of peaks was observed when the hemoperfusion was performed using the polyetherurethane sheet embedded with powdered charocal (UPC) that had been newly developed mainly for the purpose of absorbing protein-bound substances. The UPC developed by the authors can successfully remove middle molecular substances in hepatic failure.

Middle molecules

High performance gel-chromatography

Charcoal

UPC

Hemoperfusion

Liver support

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 6534919