この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00038290
Hiroshima Journal of Medical Sciences Volume 33 Issue 4
published_at 1984-12
Nonspecific Mitogen Responses of Peripheral Lymphocytes in Levamisole-Treated Patients with Herpetic Stromal Keratitis
実質型角膜ヘルペス患者の mitogen response について
Sakata Hiroshi
Hiyama Noboru
Kondo Hideaki
Hirakawa Yuji
Yoshida Hideto
Abstract
For the purpose of determining the effect of levamisole on cell-mediated immunity of patients with herpetic stromal keratitis, the response of peripheral lymphocytes to three mitogens (PHA, Con A and PWM) was examined in a total of 19 cases of herpetic stromal keratitis (16 effective cases) including 12 patients undergoing levamisole administration.
As controls, a similar study was made on 35 healthy individuals without any ocular disease and on 19 patients with herpetic stromal keratitis who underwent steroid therapy.
The response of lymphocytes to the three types of mitogens in cases undergoing levamisole therapy did not show any significant difference from that of healthy individuals.
The response of peripheral lymphocytes to PHA and Con A in cases more than 7 months after cessation d levamisole administration and in cases undergoing steroid therapy was significantly elevated when compared with that of healthy cases.
These results suggest that levamisole posseses the action of modulating the function of chiefly T-cells among the lymphocytes, through which it is effective against herpetic stromal keratitis.
As controls, a similar study was made on 35 healthy individuals without any ocular disease and on 19 patients with herpetic stromal keratitis who underwent steroid therapy.
The response of lymphocytes to the three types of mitogens in cases undergoing levamisole therapy did not show any significant difference from that of healthy individuals.
The response of peripheral lymphocytes to PHA and Con A in cases more than 7 months after cessation d levamisole administration and in cases undergoing steroid therapy was significantly elevated when compared with that of healthy cases.
These results suggest that levamisole posseses the action of modulating the function of chiefly T-cells among the lymphocytes, through which it is effective against herpetic stromal keratitis.
About This Article
Keywords
Herpetic stromal keratitis
Levamisole
Nonspecific mitogen response
Other Article
PP. 571 - 575
PP. 585 - 589
PP. 591 - 594
PP. 595 - 598
PP. 607 - 614
PP. 615 - 618
PP. 619 - 624
PP. 649 - 657
PP. 659 - 662
PP. 679 - 683
PP. 715 - 720
PP. 727 - 730
PP. 747 - 754
PP. 755 - 758
PP. 759 - 763
PP. 771 - 774
PP. 813 - 817