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Hiroshima Journal of Medical Sciences Volume 33 Issue 4
published_at 1984-12
Distribution of GEP Endocrine Cells in the Gastric Mucosa of Mice with Experimental Gastritis
実験胃炎・胃粘膜の GEP ホルモン細胞動態
Kishimoto Shinya
Konemori Reiko
Mukai Toshikazu
Kambara Akihiko
Okamoto Kazuma
Shimizu Satoru
Iwasaki Yukiyoshi
Daitoku Kunihiko
Kajiyama Goro
Miyoshi Akima
Abstract
The aim of this study was to ascertain the morphological changes in the endocrine cell profile in the atrophic mucosa of mice with autoimmune gastritis induced by neonatal thymectomy and administration of carcinogenic chemical, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Proliferation of argyrophil cells, gastrin (G17, G34) cells in areas of pseudopyloric metaplasia, enteric hormone (GIP, secretin, substance P, enteroglucagon) containing cells and enterochromaffin cells in areas of intestinal metaplasia of the atrophic mucosa was observed in mice with autoimmune gastritis together with proliferation of enterochromaffin-like cells and undifferentiated endocrine cells in their atrophic mucosa. These findings suggest that atrophic mucosae, especially epithelia of pseudopyloric and intestinal metaplasia as well, have the potential of producing endocrine cells which are normally present in the gastric antrum and intestine.
Proliferation of argyrophil cells, gastrin (G17, G34) cells in areas of pseudopyloric metaplasia, enteric hormone (GIP, secretin, substance P, enteroglucagon) containing cells and enterochromaffin cells in areas of intestinal metaplasia of the atrophic mucosa was observed in mice with autoimmune gastritis together with proliferation of enterochromaffin-like cells and undifferentiated endocrine cells in their atrophic mucosa. These findings suggest that atrophic mucosae, especially epithelia of pseudopyloric and intestinal metaplasia as well, have the potential of producing endocrine cells which are normally present in the gastric antrum and intestine.
About This Article
Keywords
Experimental gastritis GEP hormone cells
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