Improving student achievement is a significant issue in Malawi. This study uses item response theory (IRT) to analyze students’ ability to acquire curriculum content in rural Malawi’ s primary education system. Using data from a sample of 1,476 grade 5 students across 30 public primary schools, the analysis computes two parameters of IRT—item difficulty and item discrimination—on selected test questions in the areas of English and mathematics. In English, students demonstrated skills in vocabulary and in asking and answering questions, while they had difficulty with tenses and stories. In mathematics, students’ strengths were concentrated in counting, writing numbers, and addition, while their weaknesses were concentrated in solving common fractions and in problems involving time and addition of money. Although IRT is useful for analyzing student ability, the test items being studied must meet certain assumptions before IRT can be used with them—posing a challenge in low-income countries. The findings of this study are intended to contribute to improving student skills in Malawi.