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Hiroshima Journal of Medical Sciences Volume 34 Issue 1
published_at 1985-03
Detection of Lymphocyte Subsets by Monoclonal Antibodies in Aged and Young Humans
YAMAKIDO Michio
YANAGIDA Jitsuro
ISHIOKA Shinichi
MATSUZAKA Shigeru
HOZAWA Soichiro
AKIYAMA Mitoshi
KOBUKE Kyoko
INAMIZU Tsutomu
NISHIMOTO Yukio
Abstract
With the use of Leu-series monoclonal antibodies, peripheral blood lymphocyte subsets in aged and young humans were determined.
1) In comparison with young individuals, Leu-1+ cells and Leu-2a+ cells were decreased, whereas Leu-7+ cells and Leu-3a/Leu-2a were increased in aged individuals.
2) No sex difference could be observed in lymphocyte subsets.
3) PHA response of lymphocytes showed a negative correlation with Leu-2a+ cells and a positive correlation with Leu-3a/Leu-2a in aged individuals.
1) In comparison with young individuals, Leu-1+ cells and Leu-2a+ cells were decreased, whereas Leu-7+ cells and Leu-3a/Leu-2a were increased in aged individuals.
2) No sex difference could be observed in lymphocyte subsets.
3) PHA response of lymphocytes showed a negative correlation with Leu-2a+ cells and a positive correlation with Leu-3a/Leu-2a in aged individuals.
About This Article
Keywords
Lymphocyte subset
Monoclonal antibody
Leu series
Aging
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