Hiroshima Journal of Medical Sciences Volume 34 Issue 1
published_at 1985-03

Detection of Lymphocyte Subsets by Monoclonal Antibodies in Aged and Young Humans

YAMAKIDO Michio
YANAGIDA Jitsuro
ISHIOKA Shinichi
MATSUZAKA Shigeru
HOZAWA Soichiro
AKIYAMA Mitoshi
KOBUKE Kyoko
INAMIZU Tsutomu
NISHIMOTO Yukio
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Abstract
With the use of Leu-series monoclonal antibodies, peripheral blood lymphocyte subsets in aged and young humans were determined.
1) In comparison with young individuals, Leu-1+ cells and Leu-2a+ cells were decreased, whereas Leu-7+ cells and Leu-3a/Leu-2a were increased in aged individuals.
2) No sex difference could be observed in lymphocyte subsets.
3) PHA response of lymphocytes showed a negative correlation with Leu-2a+ cells and a positive correlation with Leu-3a/Leu-2a in aged individuals.
Keywords
Lymphocyte subset
Monoclonal antibody
Leu series
Aging