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Hiroshima Journal of Medical Sciences 34 巻 1 号
1985-03 発行
Interleukin-2 Production and Lymphocyte Proliferation in Aged and Young Humans
YAMAKIDO Michio
YANAGIDA Jitsuro
ISHIOKA Shinichi
MATSUZAKA Shigeru
HOZAWA Soichiro
AKIYAMA Mitoshi
KOBUKE Kyoko
INAMIZU Tsutomu
NISHIMOTO Yukio
Abstract
A study was made on the effect of aging on the production of Interleukin-2 (IL-2) and lymphocyte proliferation of human peripheral blood lymphocytes.
1) In comparison with young individuals, IL-2 production tended to decrease in aged individuals, while lymphocyte proliferation showed a significant decrease.
2) A significant correlation was observed between IL-2 production and lymphocyte proliferation in both the aged and young human populations.
3) IL-2 production showed a negative correlation with Leu-2a positive rate and a positive correlation with Leu-3a/Leu-2a ratio in aged individuals.
1) In comparison with young individuals, IL-2 production tended to decrease in aged individuals, while lymphocyte proliferation showed a significant decrease.
2) A significant correlation was observed between IL-2 production and lymphocyte proliferation in both the aged and young human populations.
3) IL-2 production showed a negative correlation with Leu-2a positive rate and a positive correlation with Leu-3a/Leu-2a ratio in aged individuals.
About This Article
著者キーワード
Interleukin-2 production
Lymphocyte proliferation
Human peripheral blood
lymphocytes
Aging
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