Experimental Studies on Acute Gastric Mucosal Lesion Involved with Obstructive Jaundice: Mainly on the Changes of Amine Contents in the Gastric Mucosa on Cold Restraint Stress

The authors gave load of cold restraint stress to rats with obstructive jaundice and those on which biliary drainage was performed in order to examine the incidence of AGML, amine contents in the gastric mucosa, and gastric mucosal microcirculation, and the following results were obtained:
1) The incidence of AGML in the 3,4-week group of rats with obstructive jaundice and in the 4-week group of rats with biliary drainage after cold restraint for 30 min was increased markedly by 78% for each as compared with 22% in the control group.
2) The contents of histamine and serotonin in the gastric mucosa in the control group showed no significant change after cold restraint for 30 min, whereas the contents of both amines in the 3,4-week group of rats with obstructive jaundice and in the 4-week group of rats with biliary drainage were, respectively, significantly decreased after cold restraint.
3) Gastric mucosal microcirculation in the control group was prevented rather successfully, whereas that in the 4-week group of rats with obstructive jaundice after cold restraint for 30 min developed disturbance of gastric mucosal microcirculation due to congestion.