Scirrhous Endocrine Cell Carcinoma of the Stomach with Synchronous Production of Six Polypeptide Hormones and Glycoproteins. A Case Report.

A case of scirrhous endocrine cell carcinoma of the stomach in a twenty-nine-yearold man was reported. Histologically, the tumor showing poorly differentiated adenocarcinoma with dense stromal fibrosis, was composed predominantly of tumor cells demonstrating positive argyrophil reaction by Grimelius staining. Immunohistochemically, they revealed the immunoreactivities to gastrin, somatostatin, glucagon, glicentin, pancreatic polypeptide and calcitonin in variable degree. Moreover, synchronous production of carcinoembryonic antigen (CEA), secretory component, lysozyme and mucin were also demonstrated. In view of the multidirectional differentiation, the scirrhous endocrine cell carcinoma might be derived from totipotent stem cell of endodermal origin.