Two Cases of Dizygotic Twins with Androgenetic Mole and Normal Conceptus

Two cases showing a molar placenta with a fetus/infant were analyzed for karyotype and enzyme polymorphisms and found to be dizygotic twin pregnancies with an androgenetic mole and a normal conceptus. One case resulted in spontaneous abortion at 19 weeks' gestation and was subsequently diagnosed as an invasive mole and required chemotherapy. The other case was a conception following clomiphene plus human menopausal gonadotropin (HMG) therapy and resulted in a normal female infant
born at 33 weeks.
It is emphasized that, since dizygotic twins in which one is an androgenetic mole have a high propensity for malignancy, they should be carefully differentiated from partial moles with which they might be confused by analysis of genetic polymorphisms and they should be followed up with care.