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Hiroshima Journal of Medical Sciences 32 巻 3 号
1983-09 発行
Zinc Content in Liver of Experimental Fulminant Hepatic Failure Rat : Significance as Index to Hepatic Injury and Regeneration
実験的急性肝不全ラットにおける肝亜鉛量の変動 : 肝障害及び再生の指標としての意義
Kawanishi Hideki
Nishiki Masayuki
Tsuchiya Taro
Ezaki Haruo
Abstract
A rat model of fulminant hepatic failure induced by D-galactosamine (Gal) was given glucagon and insulin. The amount of Zn contained in its liver was measured and investigated for use as an index to the progress of hepatic failure and to the hepatic regeneration.
The results showed that the Zn content in the rat's liver had been rapidly reduced to the lowest value 48 hours after Gal was given before the morphological change occurred. Also, a significant improvement was observed in the Zn content in liver by giving glucagon and insulin. As a result, it is suggested that the Zn content can be used as an index to the degree of hepatocyte injury and regeneration.
The results showed that the Zn content in the rat's liver had been rapidly reduced to the lowest value 48 hours after Gal was given before the morphological change occurred. Also, a significant improvement was observed in the Zn content in liver by giving glucagon and insulin. As a result, it is suggested that the Zn content can be used as an index to the degree of hepatocyte injury and regeneration.
About This Article
著者キーワード
Hepatic failure
Zn content in liver
Hepatocyte volume fraction
Insulin and glucagon
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