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Hiroshima Journal of Medical Sciences 32 巻 3 号
1983-09 発行
Levels of Cyclic-AMP, Cyclic-GMP and Betamethasone in the Aqueous Humor Following Topical Administration of Betamethasone in Rabbit Eyes
Betamethasone 点眼投与後の前房水中および血中 Betamethasone 濃度と，前房水中 cAMP, cGMP 濃度の経時的変化
Baba Saeko
Mishima Hiromu
Miyachi Yukitaka
Abstract
The levels of cyclic-AMP, cyclic-GMP and betamethasone (BM) in the aqueous humor and serum BM following topical treatment with BM were determined using radioimmunoassay (RIA) methods. One drop of a solution containing 0.1%, 0.5% or 1.0% BM was applied to the rabbit eye of 6 rabbits. The left eyes served as controls.
BM was detected in the aqueous humor from right eyes 15 minutes after administration and peaked in 60-90 minutes. BM was also detected in the aqueous humor of the left eyes and in serum.
Basal levels of cAMP and cGMP in the aqueous humor before BM treatment were 61.5 and 4.1 picomole/ml respectively, and changed little after BM treatment.
BM was detected in the aqueous humor from right eyes 15 minutes after administration and peaked in 60-90 minutes. BM was also detected in the aqueous humor of the left eyes and in serum.
Basal levels of cAMP and cGMP in the aqueous humor before BM treatment were 61.5 and 4.1 picomole/ml respectively, and changed little after BM treatment.
About This Article
著者キーワード
Cyclic-nucleotide
Betamethasone
Aqueous humor
Radioimmunoassay
Other Article
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