Levels of Cyclic-AMP, Cyclic-GMP and Betamethasone in the Aqueous Humor Following Topical Administration of Betamethasone in Rabbit Eyes
Hiroshima Journal of Medical Sciences 32 巻 3 号
301-304 頁
1983-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Levels of Cyclic-AMP, Cyclic-GMP and Betamethasone in the Aqueous Humor Following Topical Administration of Betamethasone in Rabbit Eyes
|
| タイトル ( jpn ) |
Betamethasone 点眼投与後の前房水中および血中 Betamethasone 濃度と，前房水中 cAMP, cGMP 濃度の経時的変化
|
| 作成者 |
Baba Saeko
Mishima Hiromu
Miyachi Yukitaka
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 32 |
| 号 | 3 |
| 開始ページ | 301 |
| 終了ページ | 304 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
The levels of cyclic-AMP, cyclic-GMP and betamethasone (BM) in the aqueous humor and serum BM following topical treatment with BM were determined using radioimmunoassay (RIA) methods. One drop of a solution containing 0.1%, 0.5% or 1.0% BM was applied to the rabbit eye of 6 rabbits. The left eyes served as controls.
BM was detected in the aqueous humor from right eyes 15 minutes after administration and peaked in 60-90 minutes. BM was also detected in the aqueous humor of the left eyes and in serum. Basal levels of cAMP and cGMP in the aqueous humor before BM treatment were 61.5 and 4.1 picomole/ml respectively, and changed little after BM treatment. |
| 著者キーワード |
Cyclic-nucleotide
Betamethasone
Aqueous humor
Radioimmunoassay
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| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
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| 発行日 | 1983-09 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6315641
|
