The purpose of this study was to explore the relationships between workers’ vigor, social support, job satisfaction, and job control among Japanese workers. A total of 65 workers in manufacturing companies completed questionnaire survey measured vigor, social support (supervisor support, coworker support), job satisfaction (satisfaction with employee relations, satisfaction with usage of their own abilities), and job control. Multiple regression analysis indicated that vigor was associated with coworker support, satisfaction with employee relations, satisfaction with usage of their own abilities, and job control. To enhance social support, job satisfaction, and job control at work, may improve workers’ vigor.