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Hiroshima Journal of Medical Sciences Volume 35 Issue 2
published_at 1986-06

Experimental Model of Gastritis Induced by Sodium Taurocholate in Rats

KISHIMOTO Shinya
OGAWA Mitsuyo
TAKABA Norio
KAMBARA Akihiko
OKAMOTO Kazuma
SHIMIZU Satoru
KUNITA Toshio
DAITOKU Kunihiko
KAJIYAMA Goro
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HiroshimaJMedSci_35_143.pdf
Abstract
Experimental gastritis was produced in rats by administration of sodium taurocholate (5 mM) for 3 months. The gastritis was associated with mucosal surface injury (erosion), inflammatory cell infiltration and proliferation of interstitial fibrosis in the gastric mucosa. The number of parietal cells per unit area and the mucosal thickness, however, were not different from those in the normal mucosa, indicating that this kind of gastritis was not atrophic but erosive gastritis. The model of erosive gastritis is most useful in studies on gastroprotection and various drugs.
About This Article
Keywords
Gastritis
Taurocholic acid
Erosion
Fibrosis
Parietal cells
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