The efficacy of topical application of sugar and povidone-iodine in the treatment of decubitus ulcers was evaluated in 15 aged patients having 25 ulcers. The sizes of decubitus ulcers hardly decreased significantly and somewhat failed to debride the wound of eschar easily because of making the wound surface extremely dry. Meanwhile, the advantages of this treatment are that sugar and povidone-iodine has a painless germicidal effect as well as topical antibiotics and that it is cheaper than other standard care. Thus, there is the possibility that its use in therapy can be one of the useful methods to prevent the development of septicemia in the management of decubitus ulcers.