A Cytogenetic Study of Heavy Mental Retardates I. A study on heavy mental retardates with cerebral palsy

A cytogenetic study was made on heavy mentally retarded patients with cerebral palsy. The purpose of this study was to get a glimpse of the causes of mental retardation and cerebral palsy. As the results, chromosome abnormalities were found in 8.6% of the patients. By this study, it was revealed that chromosome abnormalities contribute significantly to the etiology of cerebral palsy.
The 58 cases examined in this study were admitted to National Sanatorium Kamo Hospital and Hiroshima Prefectural Handicapped Children's Hospital.
Chromosome slides were prepared in accordance with standard blood culture procedure. Karyotype analyses were made with the application of the conventional Giemsa staining and G-, C-, and Q-banding differential staining.
Of these 58 cases, 5 cases had abnormal karyotypes, showing an incidence of 8.6%. Of 5 abnormal karyotype cases, autosomal abnormalities were observed in 3 cases, and sex-chromosome abnormalities in 2 cases. And additional 4 cases had normal variations of no.1, 9, and Y chromosome. The clinical and cytogenetic findings of these patients were presented.