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Hiroshima Journal of Medical Sciences 42 巻 1 号
1993-03 発行
A Study on the Lung Function in α1-antitrypsin-deficient (PiMZ) Patients
Kambe Masayuki
Morishita Kazuhiko
Tsubokura Tokuo
Tsuno Ken-ichiro
Kimura Toshiki
Utsumi Toshio
Kawamoto Hitoshi
Yamakido Michio
Mittman Charles
Abstract
Laurel and Eriksson published the first report indicating that a1-antitrypsin deficiency predisposed patients to the development of Chronic Obstructive Pulmonary Disease (COPD).
For the purpose of early detection, disturbances of pulmonary function in a1-antitrypsin mild deficiency cases (PiMZ) were compared with those of normal cases (PiMM) in caucasian Americans.
The marked results are as follows.
1) Parameters of flow-volume curves were more disturbed in PiMZ cases than in PiMM cases.
2) Volumes of isoflow are specially different between PiMZ and PiMM cases.
3) Mechanical properties, like lung work of breathing, were larger in PiMZ cases than in PiMM cases.
For the purpose of early detection, disturbances of pulmonary function in a1-antitrypsin mild deficiency cases (PiMZ) were compared with those of normal cases (PiMM) in caucasian Americans.
The marked results are as follows.
1) Parameters of flow-volume curves were more disturbed in PiMZ cases than in PiMM cases.
2) Volumes of isoflow are specially different between PiMZ and PiMM cases.
3) Mechanical properties, like lung work of breathing, were larger in PiMZ cases than in PiMM cases.
About This Article
著者キーワード
Pulmonary emphysema
α1-antitrypsin
PiMZ type
Pulmonary function
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