A Study on the Lung Function in α1-antitrypsin-deficient (PiMZ) Patients

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Title ( eng )
A Study on the Lung Function in α1-antitrypsin-deficient (PiMZ) Patients
Creator
Kambe Masayuki
Morishita Kazuhiko
Tsubokura Tokuo
Tsuno Ken-ichiro
Kimura Toshiki
Utsumi Toshio
Kawamoto Hitoshi
Yamakido Michio
Mittman Charles
Source Title
Hiroshima Journal of Medical Sciences
Volume 42
Issue 1
Start Page 41
End Page 45
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Laurel and Eriksson published the first report indicating that a1-antitrypsin deficiency predisposed patients to the development of Chronic Obstructive Pulmonary Disease (COPD).

For the purpose of early detection, disturbances of pulmonary function in a1-antitrypsin mild deficiency cases (PiMZ) were compared with those of normal cases (PiMM) in caucasian Americans.

The marked results are as follows.
1) Parameters of flow-volume curves were more disturbed in PiMZ cases than in PiMM cases.
2) Volumes of isoflow are specially different between PiMZ and PiMM cases.
3) Mechanical properties, like lung work of breathing, were larger in PiMZ cases than in PiMM cases.
Keywords
Pulmonary emphysema
α1-antitrypsin
PiMZ type
Pulmonary function
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 1993-03
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 8486520