A Study on the Lung Function in α1-antitrypsin-deficient (PiMZ) Patients

Kambe Masayuki

Morishita Kazuhiko

Tsubokura Tokuo

Tsuno Ken-ichiro

Kimura Toshiki

Utsumi Toshio

Kawamoto Hitoshi

Yamakido Michio

Mittman Charles

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

Laurel and Eriksson published the first report indicating that a1-antitrypsin deficiency predisposed patients to the development of Chronic Obstructive Pulmonary Disease (COPD).

For the purpose of early detection, disturbances of pulmonary function in a1-antitrypsin mild deficiency cases (PiMZ) were compared with those of normal cases (PiMM) in caucasian Americans.

The marked results are as follows.
1) Parameters of flow-volume curves were more disturbed in PiMZ cases than in PiMM cases.
2) Volumes of isoflow are specially different between PiMZ and PiMM cases.
3) Mechanical properties, like lung work of breathing, were larger in PiMZ cases than in PiMM cases.

Pulmonary emphysema

α1-antitrypsin

PiMZ type

Pulmonary function

医学 [ 490 ]

英語

Hiroshima University Medical Press

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 8486520