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Hiroshima Journal of Medical Sciences Volume 32 Issue 4
published_at 1983-12

VIPergic Innervation in the Gastrointestinal Tract of Diabetic Rats

糖尿病ラットの消化管における VIP 作動神経
Kishimoto Shinya
Kunita Satoko
Kambara Akihiko
Okamoto Kazuma
Shimizu Satoru
Yamamoto Masahiro
Koh Hassei
Sano Kohichi
Kajiyama Goro
Miyoshi Akima
Yanaihara Noboru
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Abstract
Diabetic gastroenteropathy developed in about 70% of the rats with diabetes induced by streptozotocin. These rats were associated with diarrhea, gastric paresis, and small intestinal stasis. About 30% of the rats with diabetic gastroenteropathy had narrowed and contracted segments of the lower esophagus and 70% of the colon of the rats showed dilated and contracted segments. Changes in the distribution of VIP-like immunoreactivities in nerve plexuses of the gastrointestinal wall which were observed with destruction of the autonomic nerves (both submucosal and myenteric plexuses) could be one of the plausible causes of diabetic gastroenteropathy induced by streptozotocin, although the precise mechanism of the development of diabetic gastroenteropathy in rats remains obscure.
About This Article
Keywords
Diabetes
Gastroenteropathy
VJP nerves
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