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Hiroshima Journal of Medical Sciences Volume 32 Issue 4
published_at 1983-12

Analysis of Hepatic Failure Plasma by High Performance Gel-Chromatography

高速ゲルクロマトグラフィーによる肝不全血漿の分析
Kawanishi Hideki
Nishiki Masayuki
Sugiyama Masafumi
Kimura Sosuke
Tsuchiya Taro
Ezaki Haruo
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HiroshimaJMedSci_32_451.pdf
Abstract
Plasma taken from hepatic failure rats induced by D-galactosamine was used to observe the variatiation in its chromatogram obtained by conducting a high performance gel-chromatography (TSK G2000SW used). The progress of hepatic failure caused distinct increase in the 12 abnormal peaks, especially peak b contained middle molecular weight substances, which showed a good correlation with the condition of progressing hepatic failure. Thus, the measurement of variation in gel-chromatogram, especially, in peak b, is effectives as a parameter of hepatic failure in progress.
About This Article
Keywords
Hepatic failure
D-galactosamine
High performance gel-chromatography
Middle molecular substance
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