VIPergic Innervation in the Gastrointestinal Tract of Diabetic Rats

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Title ( eng )
VIPergic Innervation in the Gastrointestinal Tract of Diabetic Rats
Title ( jpn )
糖尿病ラットの消化管における VIP 作動神経
Creator
Kishimoto Shinya
Kunita Satoko
Kambara Akihiko
Okamoto Kazuma
Shimizu Satoru
Yamamoto Masahiro
Koh Hassei
Sano Kohichi
Kajiyama Goro
Miyoshi Akima
Yanaihara Noboru
Source Title
Hiroshima Journal of Medical Sciences
Volume 32
Issue 4
Start Page 469
End Page 478
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Diabetic gastroenteropathy developed in about 70% of the rats with diabetes induced by streptozotocin. These rats were associated with diarrhea, gastric paresis, and small intestinal stasis. About 30% of the rats with diabetic gastroenteropathy had narrowed and contracted segments of the lower esophagus and 70% of the colon of the rats showed dilated and contracted segments. Changes in the distribution of VIP-like immunoreactivities in nerve plexuses of the gastrointestinal wall which were observed with destruction of the autonomic nerves (both submucosal and myenteric plexuses) could be one of the plausible causes of diabetic gastroenteropathy induced by streptozotocin, although the precise mechanism of the development of diabetic gastroenteropathy in rats remains obscure.
Keywords
Diabetes
Gastroenteropathy
VJP nerves
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University School of Medicine
Date of Issued 1983-12
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6678903