VIPergic Innervation in the Gastrointestinal Tract of Diabetic Rats

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タイトル ( eng )
VIPergic Innervation in the Gastrointestinal Tract of Diabetic Rats
タイトル ( jpn )
糖尿病ラットの消化管における VIP 作動神経
作成者
Kishimoto Shinya
Kunita Satoko
Kambara Akihiko
Okamoto Kazuma
Shimizu Satoru
Yamamoto Masahiro
Koh Hassei
Sano Kohichi
Kajiyama Goro
Miyoshi Akima
Yanaihara Noboru
収録物名
Hiroshima Journal of Medical Sciences
32
4
開始ページ 469
終了ページ 478
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
Diabetic gastroenteropathy developed in about 70% of the rats with diabetes induced by streptozotocin. These rats were associated with diarrhea, gastric paresis, and small intestinal stasis. About 30% of the rats with diabetic gastroenteropathy had narrowed and contracted segments of the lower esophagus and 70% of the colon of the rats showed dilated and contracted segments. Changes in the distribution of VIP-like immunoreactivities in nerve plexuses of the gastrointestinal wall which were observed with destruction of the autonomic nerves (both submucosal and myenteric plexuses) could be one of the plausible causes of diabetic gastroenteropathy induced by streptozotocin, although the precise mechanism of the development of diabetic gastroenteropathy in rats remains obscure.
著者キーワード
Diabetes
Gastroenteropathy
VJP nerves
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University School of Medicine
発行日 1983-12
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6678903