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Hiroshima Journal of Medical Sciences 32 巻 2 号
1983-06 発行
Effects of Atrophic Changes in Mucosa and Endogenous Gastrin (Hypergastrinemia) on Development of Experimental Gastric Cancer and its Growth in Rats : A Pilot Study
萎縮性胃炎とガストリンの実験胃癌に及ぼす影響
Kishimoto Shinya
Kunita Satoko
Shimizu Satoshi
Koh Hassei
Yamamoto Masahiro
Kajiyama Goro
Miyoshi Akima
Abstract
In the present experiment the influence of atrophic mucosa and resulting endogenous hypergastrinemia on the induction of gastric cancer by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was examined in male Donryu rats. All rats were fed MNNG in tap water for 6 months and were killed after more 5 months. The incidence of gastric cancer was 55% in rats with atrophic gastritis and hypergastrinemia, which is significantly higher than the incidence of 10 % observed in rats treated with MNNG alone. Gastric cancer was not found in any rats with atrophic gastritis without associating with hypergastrinemia. These data suggest that atrophic mucosa and resulting hypergastrinemia are important in development and growth of gastric cancer in rats.
About This Article
内容記述
This work was supported by a grant from the Ministry of Education (1976-1977).
著者キーワード
Experimental atropic gastritis
Gastric cancer
Gastrin
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