Effects of Atrophic Changes in Mucosa and Endogenous Gastrin (Hypergastrinemia) on Development of Experimental Gastric Cancer and its Growth in Rats : A Pilot Study
Hiroshima Journal of Medical Sciences 32 巻 2 号
213-218 頁
1983-06 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Effects of Atrophic Changes in Mucosa and Endogenous Gastrin (Hypergastrinemia) on Development of Experimental Gastric Cancer and its Growth in Rats : A Pilot Study
|
| タイトル ( jpn ) |
萎縮性胃炎とガストリンの実験胃癌に及ぼす影響
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| 作成者 |
Kishimoto Shinya
Kunita Satoko
Shimizu Satoshi
Koh Hassei
Yamamoto Masahiro
Kajiyama Goro
Miyoshi Akima
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| 収録物名 |
Hiroshima Journal of Medical Sciences
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| 巻 | 32 |
| 号 | 2 |
| 開始ページ | 213 |
| 終了ページ | 218 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
In the present experiment the influence of atrophic mucosa and resulting endogenous hypergastrinemia on the induction of gastric cancer by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was examined in male Donryu rats. All rats were fed MNNG in tap water for 6 months and were killed after more 5 months. The incidence of gastric cancer was 55% in rats with atrophic gastritis and hypergastrinemia, which is significantly higher than the incidence of 10 % observed in rats treated with MNNG alone. Gastric cancer was not found in any rats with atrophic gastritis without associating with hypergastrinemia. These data suggest that atrophic mucosa and resulting hypergastrinemia are important in development and growth of gastric cancer in rats.
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| 著者キーワード |
Experimental atropic gastritis
Gastric cancer
Gastrin
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| 内容記述 |
This work was supported by a grant from the Ministry of Education (1976-1977).
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
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| 発行日 | 1983-06 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 6618902
|
