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Hiroshima Journal of Medical Sciences 32 巻 1 号
1983-03 発行

Basic Study of Polyetherurethane Coated Bead-Type Activated Charcoal for Direct Hemoperfusion

ポリエーテル型ウレタン被覆ビーズ状活性炭を用いた血液直接灌流の基礎研究
Kawanishi Hideki
Nishiki Masayuki
Sugiyama Masafumi
Cho Tsuneo
Tsuchiya Taro
Ezaki Haruo
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HiroshimaJMedSci_32_9.pdf
Abstract
A new type of activated charcoal for the direct hemoperfusion (DHP) has been developed for use in treatment of fulminant hepatic failure. Bead-type activated charcoal from petroleum pitch (BAC) was coated with polyetherurethane. The coating has permitted the charcoal to minimize the number of released microparticles and yet to show nearly the same adsorption performance as that of the non-coated BAC in vitro adsorption test. DHP using a fulminant hepatic failure dog induced by hepatic ischemia has shown improved consciousness and good biocompatibility as well as good clearance of toxic substances. As above, the newly developed bead-type activated charcoal coated with polyetherurethane can be considered effective in treatment of fulminant hepatic failure.
About This Article
著者キーワード
Liver support system
Activated charcoal
Polyetherurethane
Hemoperfusion
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