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Hiroshima Journal of Medical Sciences 45 巻 2 号
1996-06 発行
Superoxide Dismutase Activity in Arthropathy : Its Role and Measurement in the Joints
Sumii Hiroshi
Inoue Hajime
Onoue Jinichi
Mori Akitane
Oda Takuzo
Tsubokura Tokuo
Abstract
The electron spin resonance (ESR) method was used to measure the superoxide dismutase (SOD) activity in synovial fluids from the knee joints of 73 patients with rheumatoid arthritis (RA), and the results were compared with those of 50 patients with osteoarthritis (QA) and posttraumatic arthritis (PA). The SOD activity in RA and OA knee joint fluids was higher than in the control patients with PA. Patients with moderate RA (grade III or IV according to Larsen's classification of rheumatoid knee radiographs) showed higher SOD activities in joint fluids than patients with early (grade I or II) and terminal (grade V) stages of RA. Our results suggest that the SOD activity in joint fluids is a valid index of articular destruction and repair.
About This Article
内容記述
This study was supported in part by grants from the Japan Association for Advancement in Medical Equipment, Okayama Prefectural Health and Welfare Department, and Research Projects of Hiroshima Prefectural College of Health and Welfare.
著者キーワード
Electron spin resonance (ESR)
Superoxide dismutase (SOD)
Rheumatoid arthritis(RA)
Osteoarthritis(OA)
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