Hiroshima Journal of Medical Sciences 39 巻 3 号
1990-09 発行

Coronary Sclerosis Risk Factors in Males with Special Reference to Lipoproteins and Apoproteins : Establishing an Index

Kawanishi Masahiro
Nakamoto Atsuko
Konemori Gen
Horiuchi Itaru
Kajiyama Goro
全文
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HiroshimaJMedSci_39_61.pdf
Abstract
In order to ascertain the most effective index for predicting coronary sclerosis, the concentration of lipids, lipoproteins, and apoproteins in serum were determined in 45 males aged over 44 with angiographically diagnosed effort angina and in 153 male controls aged over 44 without ischemic heart disease (IHD) on physical examination. The results of our study are summarized as follows.   

1) Alcohol intake of 25 g/day or more and smoking of 20 cigarettes/day or more showed significant odds ratios of 0.47 and 2.33, respectively.   
2) By decrease of 10 mg/dl in HDLC level or of 10 mg/dl in Apo-AI level, the possibility of coronary sclerosis increases twofold after adjusting the effects of confounders.   
3) LDLC/HDLC and Apo-B/Apo-AI are effective indices for predicting coronary sclerosis and, in particular, the probability of coronary sclerosis increases 3.8 times by increase of 0.5 in Apo-B/Apo-AI.
著者キーワード
Lipoproteins
Apoproteins
Multiple logistic regression
Odds ratio