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Hiroshima Journal of Medical Sciences Volume 38 Issue 1
published_at 1989-03

Nephrotoxicity of Pyrroloquinoline Quinone in Rats

Watanabe Akiharu
Hobara Norio
Ohsawa Toshiya
Higashi Toshihiro
Tsuji Takao
fulltext
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HiroshimaJMedSci_38_49.pdf
Abstract
When pyrroloquinoline quinone (PQQ) was intraperitoneally injected into rats daily for 4 days at a dose of 11.5 mg/kg body weight/injection, functional and morphologic changes of the kidneys were clearly observed. The most prominent finding was necrotic and degenerative changes of the proximal tubular epithelium as well as hematuria and an elevation of serum creatinine concentration.
About This Article
Keywords
Nephrotoxicity
Pyrroloquinoline quinone
Renal tubules
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