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Hiroshima Journal of Medical Sciences Volume 36 Issue 4
published_at 1987-12

Elevation of Ammonia Contents in the Cerebral Hemisphere under the Blood-Brain Barrier Opening

WATANABE Akiharu
FUJIWARA Masachika
TOMINAGA Satoru
NAGASHIMA Hideo
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HiroshimaJMedSci_36_415.pdf
Abstract
Elevation of ammonia contents was observed 1 hr following infusion of 4% ammonium acetate only in the cerebral hemisphere where reversible opening of the blood-brain barrier was induced by intracarotid injection of 0.1% deoxycholic acid. This finding suggests that ammonia may contribute to hepatic encephalopathy, when the permeability of the blood-brain barrier is altered.
About This Article
Keywords
Brain ammonia
Blood-brain barrier
Hyperammonemia
Bile acid
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