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Hiroshima Journal of Medical Sciences 35 巻 3 号
1986-09 発行

In Vitro Thermochemotherapy of Human Osteosarcoma Cells with Cis-Dichlorodiammineplatinum (II)

YAMANE Takashi
NAKABAYASHI Hidekazu
ITO Shiro
SUMII Hiroshi
KAWAI Akira
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HiroshimaJMedSci_35_191.pdf
Abstract
Human osteosarcoma cells (HuO-3Nl cells) and fibroblastic cells with normal human karyotype (HuO-3 cells) were derived from a patient with osteosarcoma. HuO-3N1 cells were more sensitive to heat treatment than HuO-3 cells. The combination of heat and cis-dichlorodiammineplatinum (II) (CDDP) exerted synergistic cytotoxity on HuO-3N1 cells, and was much less cytotoxic to HuO-3 cells than to HuO-3Nl cells. Therefore, thermochemotherapy with CDDP may be useful for treatment of human osteosarcoma.
About This Article
著者キーワード
Tissue culture
Thermochemotherapy
Human osteosarcoma cell
Cis-dichlorodiammineplatinum (II)
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