The Influence of Truncal Vagotomy on Acute Gastric Mucosal Lesion in Obstructive Jaundice

With a view to examining the influence of truncal vagotomy on acute gastric mucosal lesion (AGML) in obstructive jaundice, the authors prepared the non-vagotomized group and the vagotomized group of rats with obstructive jaundice. Further, cold restraint stress was loaded on the two groups for 30 min, and the following results were obtained:
1) The incidence of AGML in the vagotomized group before stress was inhibited to 17% in both the 3-week group and 4-week group, as compared to 33-38% in the non-vagotomized group. The incidence of AGML in the vagotomized group after stress was inhibited to 17% in the 3-week group and 33% in the 4-week group, as compared to 78% in the non-vagotomized group.
2) Gastric mucosal histamine (HA) contents in the vagotomized group before stress in both the 3-week group and the 4-week group were significantly increased (p < 0.05) as compared with the levels in the non-vagotomized group. As concerns gastric mucosal serotonin (5-HT) contents, however, no significant difference was noted between both groups. The contents of both amines in the gastric mucosa in the non-vagotomized group, a significant decrease (p < 0.05) was observed in both the 3-week group and 4-week group after stress, while in the vagotomized group no significant changes were found.