Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation

Hirano Harutoyo

Takama Renjo

Matsumoto Ryo

Tanaka Hiroshi

Hirano Hiroki

Soh Zu

Ukawa Teiji

Takayanagi Tsuneo

Morimoto Haruka

Nakamura Ryuji

Saeki Noboru

Hashimoto Haruki

Matsui Shogo

Kishimoto Shinji

Oda Nozomu

Kajikawa Masato

Maruhashi Tatsuya

Kawamoto Masashi

Yoshizumi Masao

Higashi Yukihito

Tsuji Toshio

Scientific Reports

This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject’s lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application.

eng

Nature Research

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[ISSN] 2045-2322

[DOI] 10.1038/s41598-018-27392-3

[DOI] https://doi.org/10.1038/s41598-018-27392-3