Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation

Scientific Reports Volume 8 Page 9263- published_at 2018-06-18
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Title ( eng )
Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation
Creator
Hirano Harutoyo
Takama Renjo
Matsumoto Ryo
Tanaka Hiroshi
Hirano Hiroki
Ukawa Teiji
Takayanagi Tsuneo
Morimoto Haruka
Nakamura Ryuji
Hashimoto Haruki
Matsui Shogo
Oda Nozomu
Source Title
Scientific Reports
Volume 8
Start Page 9263
Abstract
This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject’s lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application.
Descriptions
This work was supported by JSPS KAKENHI Grant Number 16K21076.
Language
eng
Resource Type journal article
Publisher
Nature Research
Date of Issued 2018-06-18
Rights
© The Author(s) 2018. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 2045-2322
[DOI] 10.1038/s41598-018-27392-3
[DOI] https://doi.org/10.1038/s41598-018-27392-3