Currently, the great majority of VLBW infants can survive. But, from the long-term outcome studies, especially ELBW infants have some problems, for example, cerebral palsy, mental retardation, sensory impairments and blindness. Furthermore, even if an ELBW infant does not develop a major handicap or sensory impairment, he or she may have a higher risk of learning disabilities, attention deficit/hyperactivity disorders, deprivation syndrome and battered child syndrome compared to full-term infants. Consideration of these findings, we must provide developmentally supportive care for VLBW premature infants a t birth in the NICU. In our NICU, we are studying stresses of premature babies. We find lower noise levels, decreased light levels and optimal positioning promote physiologic and behavioral stability of VLBW infants. After this, we will introduce more comfortable NICU environment for normal growth and development of VLBW premature infants.