広島大学総合科学部紀要. IV, 理系編 26 巻
2000-12-28 発行

HAIRY CELL LEUKEMIA (HCL) の 12 症例の細胞学的解析

Cytology in Hairy Cell Leukemia (HCL)
和泉 堯己
小村 堯
久島 公夫
山下 美佐子
田中 公夫
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KJ00000197448.pdf
Abstract
Hairy cell leukemia (HCL) is a chronic lympho-proliferative disease. The disease is clinically characterized by anemia, granulocytopenia, thrombocytopenia, monocytopenia, splenomegaly. This leukemia cells have peculiar shape with hairlike projection, and express mature B-cell antigens such as, CD19,CD20 and Ig heavy chain on their surface. Nuclear and cytoplasm area ratio was low. Cell biological observation and chromosome analysis were performed in 12 patients. Translocation at 14q32 was found in 2 patients and loss of chromosome 6 was found in one patient. These cytogenetical results suggest taht HCL is different disease from chronic lymphocytic leukemia.
著者キーワード
Hairy cell leukemia
B-cell
chromosome aberrations