Attenuated Mycobacterium lepraemurium Vaccine Non-Protective against Mycobacterium intracellulare Infection in Mice
Hiroshima Journal of Medical Sciences 35 巻 1 号
67-69 頁
1986-03 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Attenuated Mycobacterium lepraemurium Vaccine Non-Protective against Mycobacterium intracellulare Infection in Mice
|
| 作成者 |
NAKANISHI Masanao
|
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 35 |
| 号 | 1 |
| 開始ページ | 67 |
| 終了ページ | 69 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
Since Mycobacterium lepraemurium (Mlm) is closely related to Mycobacterium intracellulare, with respect to its antigenicity, attenuated Mlm obtained by passages on 1% Ogawa egg medium was examined for possible effects as a vaccine against M. intracelJulare infection. Four weeks after subcutaneous injection of Mlm (1.4 x 107 bacilli), mice were infected intravenously with 2.4 x 107 organisms per mouse of M. intracellulare. During the first 12 weeks, no difference was noted in the rate of progression of M. intracellulare infection between mice given or not given Mlm-vaccine, when severity of the infection was measured on the basis of the number of viable M. intracellulare in the lungs and spleen. Therefore, Mlm-vaccine is probably not efficacious in protecting mice against M. intracellulare infection.
|
| 著者キーワード |
Mycobacterium lepraemurium
M. Intracellulare
Vaccination
|
| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
|
| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University School of Medicine
|
| 発行日 | 1986-03 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3528063
|
