Attenuated Mycobacterium lepraemurium Vaccine Non-Protective against Mycobacterium intracellulare Infection in Mice
Hiroshima Journal of Medical Sciences Volume 35 Issue 1
Page 67-69
published_at 1986-03
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| File | |
| Title ( eng ) |
Attenuated Mycobacterium lepraemurium Vaccine Non-Protective against Mycobacterium intracellulare Infection in Mice
|
| Creator |
NAKANISHI Masanao
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 35 |
| Issue | 1 |
| Start Page | 67 |
| End Page | 69 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Since Mycobacterium lepraemurium (Mlm) is closely related to Mycobacterium intracellulare, with respect to its antigenicity, attenuated Mlm obtained by passages on 1% Ogawa egg medium was examined for possible effects as a vaccine against M. intracelJulare infection. Four weeks after subcutaneous injection of Mlm (1.4 x 107 bacilli), mice were infected intravenously with 2.4 x 107 organisms per mouse of M. intracellulare. During the first 12 weeks, no difference was noted in the rate of progression of M. intracellulare infection between mice given or not given Mlm-vaccine, when severity of the infection was measured on the basis of the number of viable M. intracellulare in the lungs and spleen. Therefore, Mlm-vaccine is probably not efficacious in protecting mice against M. intracellulare infection.
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| Keywords |
Mycobacterium lepraemurium
M. Intracellulare
Vaccination
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1986-03 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3528063
|
