Inhibitory Effects of Pisiferic Acid on Angiogenesis and Lymphangiogenesis
Planta Medica International Open 3 巻 02 号
e31-e34 頁
2016-08-22 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Inhibitory Effects of Pisiferic Acid on Angiogenesis and Lymphangiogenesis
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| 作成者 |
Shibata Sachi
Yatagai Mitsuyoshi
Tateishi Yoshiko
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| 収録物名 |
Planta Medica International Open
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| 巻 | 3 |
| 号 | 02 |
| 開始ページ | e31 |
| 終了ページ | e34 |
| 抄録 |
Pisiferic acid, a diterpene isolated from Chamaecyparis pisifera, has a chemical structure similar to carnosic acid, which has antioxidant activity and exerts various biological effects such as antibiotic and antiangiogenic activity. However, the effect of pisiferic acid on angiogenesis, which is involved in various diseases including cancer and diabetic retinopathy, has not been elucidated. We found that pisiferic acid inhibited angiogenesis and suppressed human umbilical vein endothelial cell tube formation and proliferation but had no effect on human umbilical vein endothelial cell chemotaxis. Furthermore, in lymphangiogenesis assays, pisiferic acid inhibited lymphangiogenesis and lymphatic endothelial cell tube formation and proliferation. Together, these results suggest pisiferic acid to be a useful natural compound, such as carnosic acid, with beneficial effects on angiogenesisand lymphangiogenesis-related diseases.
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| 著者キーワード |
Chamaecyparis pisifera
Cupressaceae
pisiferic acid
angiogenesis
lymphangiogenesis
endothelial cells
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| 内容記述 |
Supporting information available online at http://www.thieme-connect.de/products
This work was supported in part by grants from JSPS KAKENHI, grant numbers 22580130 and 26450159 (K.M.). |
| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Thieme Open
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| 発行日 | 2016-08-22 |
| 権利情報 |
© Georg Thieme Verlag KG Stuttgart · New York ·
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License.
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
Planta Med Int Open 2016; 3: e31–e34
[ISSN] 2509‑6656
[ISSN] 2199-157X
[DOI] 10.1055/s-0042-107801
[DOI] https://doi.org/10.1055/s-0042-107801
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