Inhibitory Effects of Pisiferic Acid on Angiogenesis and Lymphangiogenesis
Planta Medica International Open Volume 3 Issue 02
Page e31-e34
published_at 2016-08-22
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| File | |
| Title ( eng ) |
Inhibitory Effects of Pisiferic Acid on Angiogenesis and Lymphangiogenesis
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| Creator |
Shibata Sachi
Yatagai Mitsuyoshi
Tateishi Yoshiko
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| Source Title |
Planta Medica International Open
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| Volume | 3 |
| Issue | 02 |
| Start Page | e31 |
| End Page | e34 |
| Abstract |
Pisiferic acid, a diterpene isolated from Chamaecyparis pisifera, has a chemical structure similar to carnosic acid, which has antioxidant activity and exerts various biological effects such as antibiotic and antiangiogenic activity. However, the effect of pisiferic acid on angiogenesis, which is involved in various diseases including cancer and diabetic retinopathy, has not been elucidated. We found that pisiferic acid inhibited angiogenesis and suppressed human umbilical vein endothelial cell tube formation and proliferation but had no effect on human umbilical vein endothelial cell chemotaxis. Furthermore, in lymphangiogenesis assays, pisiferic acid inhibited lymphangiogenesis and lymphatic endothelial cell tube formation and proliferation. Together, these results suggest pisiferic acid to be a useful natural compound, such as carnosic acid, with beneficial effects on angiogenesisand lymphangiogenesis-related diseases.
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| Keywords |
Chamaecyparis pisifera
Cupressaceae
pisiferic acid
angiogenesis
lymphangiogenesis
endothelial cells
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| Descriptions |
Supporting information available online at http://www.thieme-connect.de/products
This work was supported in part by grants from JSPS KAKENHI, grant numbers 22580130 and 26450159 (K.M.). |
| Language |
eng
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| Resource Type | journal article |
| Publisher |
Thieme Open
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| Date of Issued | 2016-08-22 |
| Rights |
© Georg Thieme Verlag KG Stuttgart · New York ·
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License.
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| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
Planta Med Int Open 2016; 3: e31–e34
[ISSN] 2509‑6656
[ISSN] 2199-157X
[DOI] 10.1055/s-0042-107801
[DOI] https://doi.org/10.1055/s-0042-107801
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