Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis
Human Immunology 72 巻 10 号
821-826 頁
2011-10 発行
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この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00046735
| ファイル情報(添付) | |
| タイトル ( eng ) |
Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis
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| 作成者 |
Yoshida Kengo
Ohishi Waka
Nakashima Eiji
Fujiwara Saeko
Akahoshi Masazumi
Kasagi Fumiyoshi
Hakoda Masayuki
Kyoizumi Seishi
Nakachi Kei
Hayashi Tomonori
Kusunoki Yoichiro
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| 収録物名 |
Human Immunology
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| 巻 | 72 |
| 号 | 10 |
| 開始ページ | 821 |
| 終了ページ | 826 |
| 抄録 |
This study aims to deepen understanding of lymphocyte phenotypes related to the course of hepatitis C virus (HCV) infection and progression of liver fibrosis, in a cohort of atomic-bomb survivors. The study subjects comprise three groups: 162 HCV persistently infected, 145 spontaneously cleared, and 3511 uninfected individuals. We found increased percentages of peripheral blood TH1 and total CD8 T cells and decreased percentages of NK cells in the HCV persistence group, compared with the other two groups, after adjustment for age, gender, and radiation exposure dose. Subsequently, we found that increased TH1 cell percentages in the HCV persistence group were significantly associated with an accelerated time-course reduction in platelet counts―accelerated progression of liver fibrosis―while TC1 and NK cell percentages were inversely associated with the progression. This study suggests that TH1 immunity is enhanced by persistent HCV infection, and that percentages of peripheral TH1, TC1, and NK cells may help predict progression of liver fibrosis.
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| 著者キーワード |
Cohort study
hepatitis C virus
liver fibrosis
lymphocyte subset
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| 内容記述 |
This research was based on RERF Research Protocols 3-09, 4-02, 2-00, 9-92, and was supported in part by the U.S. National Institute of Allergy and Infectious Diseases (NIAID Contract HHSN272200900059C).
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
American Society for Histocompatibility and Immunogenetics
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| 発行日 | 2011-10 |
| 権利情報 |
Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0198-8859
[ISSN] 1879-1166
[NCID] AA00214087
[DOI] 10.1016/j.humimm.2011.05.029
[DOI] https://doi.org/10.1016/j.humimm.2011.05.029
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