Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis
Human Immunology Volume 72 Issue 10
Page 821-826
published_at 2011-10
アクセス数 : 703 件
ダウンロード数 : 253 件
今月のアクセス数 : 6 件
今月のダウンロード数 : 1 件
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00046735
| File | |
| Title ( eng ) |
Lymphocyte subset characterization associated with persistent hepatitis C virus infection and subsequent progression of liver fibrosis
|
| Creator |
Yoshida Kengo
Ohishi Waka
Nakashima Eiji
Fujiwara Saeko
Akahoshi Masazumi
Kasagi Fumiyoshi
Hakoda Masayuki
Kyoizumi Seishi
Nakachi Kei
Hayashi Tomonori
Kusunoki Yoichiro
|
| Source Title |
Human Immunology
|
| Volume | 72 |
| Issue | 10 |
| Start Page | 821 |
| End Page | 826 |
| Abstract |
This study aims to deepen understanding of lymphocyte phenotypes related to the course of hepatitis C virus (HCV) infection and progression of liver fibrosis, in a cohort of atomic-bomb survivors. The study subjects comprise three groups: 162 HCV persistently infected, 145 spontaneously cleared, and 3511 uninfected individuals. We found increased percentages of peripheral blood TH1 and total CD8 T cells and decreased percentages of NK cells in the HCV persistence group, compared with the other two groups, after adjustment for age, gender, and radiation exposure dose. Subsequently, we found that increased TH1 cell percentages in the HCV persistence group were significantly associated with an accelerated time-course reduction in platelet counts―accelerated progression of liver fibrosis―while TC1 and NK cell percentages were inversely associated with the progression. This study suggests that TH1 immunity is enhanced by persistent HCV infection, and that percentages of peripheral TH1, TC1, and NK cells may help predict progression of liver fibrosis.
|
| Keywords |
Cohort study
hepatitis C virus
liver fibrosis
lymphocyte subset
|
| Descriptions |
This research was based on RERF Research Protocols 3-09, 4-02, 2-00, 9-92, and was supported in part by the U.S. National Institute of Allergy and Infectious Diseases (NIAID Contract HHSN272200900059C).
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | journal article |
| Publisher |
American Society for Histocompatibility and Immunogenetics
|
| Date of Issued | 2011-10 |
| Rights |
Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
|
| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0198-8859
[ISSN] 1879-1166
[NCID] AA00214087
[DOI] 10.1016/j.humimm.2011.05.029
[DOI] https://doi.org/10.1016/j.humimm.2011.05.029
|
